Solid pseudopapillary neoplasm of the pancreas (SPN) is relatively rare and it occurs almost exclusively in women. We recently experienced three cases of SPN diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). These three cases were two male and one female patient whose age was 29, 37, and 44 years old. Radiological diagnosis was pancreatic endocrine tumor (PEN) showing solid with a heterogenous echogenicity. EUS-FNA cytology specimens consisted of single cells and aggregates of uniform cells, forming microadenoid structures, branching, papillary clusters with delicate fibrovascular cores. In conclusion, a single diagnosis of SPN based on clinical and radiological findings would be risky because there is a possibility of it being misdiagnosed as PEN or other malignancies. An EUS-FNA is therefore essential for establishing the diagnosis. In addition, the pathologists should recognize the characteristic cytologic findings with immunoprofiles of SPN to prevent misdiagnosis of SPN.

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• Laparoscopic parenchyma-sparing resections for solid pseudopapillary tumors located in the head of pancreas
  Zhengdong Zou, Lu Feng, Bing Peng, Jianhua Liu, Yunqiang Cai
  BMC Surgery.2023;[Epub]     CrossRef
• Solid pancreatic masses in children: A review of current evidence and clinical challenges
  Kelli N. Patterson, Andrew T. Trout, Archana Shenoy, Maisam Abu-El-Haija, Jaimie D. Nathan
  Frontiers in Pediatrics.2022;[Epub]     CrossRef
• Pancreatic solid pseudopapillary neoplasm in male patients: systematic review with three new cases
  Anna Caterina Milanetto, Anna-Lea Gais Zürcher, Lorenzo Macchi, Alina David, Claudio Pasquali
  Updates in Surgery.2021; 73(4): 1285.     CrossRef
• Silencing c-Myc Enhances the Antitumor Activity of Bufalin by Suppressing the HIF-1α/SDF-1/CXCR4 Pathway in Pancreatic Cancer Cells
  Xia Liu, Yayun Zhou, Jiamin Peng, Bei Xie, Qiyang Shou, Jianchao Wang
  Frontiers in Pharmacology.2020;[Epub]     CrossRef
• Simultaneous colorectal and parenchymal-sparing liver resection for advanced colorectal carcinoma with synchronous liver metastases: Between conventional and mini-invasive approaches
  Emilio De Raffele, Mariateresa Mirarchi, Dajana Cuicchi, Ferdinando Lecce, Riccardo Casadei, Claudio Ricci, Saverio Selva, Francesco Minni
  World Journal of Gastroenterology.2020; 26(42): 6529.     CrossRef
• Solid pseudopapillary neoplasm of the pancreas showing marked distal atrophy: A case report
  Masanori Tsujie, Tomoko Wakasa, Shigeto Mizuno, Hajime Ishikawa, Hironobu Manabe, Taichi Koyama, Kotaro Kitani, Shumpei Satoi, Keisuke Inoue, Shuichi Fukuda, Toshihiko Kawasaki, Masao Yukawa, Yoshio Ohta, Masatoshi Inoue
  International Journal of Surgery Case Reports.2019; 55: 136.     CrossRef
• Solid pseudopapillary neoplasm of the pancreas in pediatric patients: A case report and institutional case series
  Justin B. Mahida, Rajan K. Thakkar, Jon Walker, Rulong Shen, Brian D. Kenney, Vinay Prasad, Jennifer H. Aldrink
  Journal of Pediatric Surgery Case Reports.2015; 3(4): 149.     CrossRef
• Onsite cytopathology evaluation and ancillary studies beneficial in EUS‐FNA of pancreatic, mediastinal, intra‐abdominal, and submucosal lesions
  Shafqat Mehmood, Amna Jahan, Asif Loya, Muhammed Aasim Yusuf
  Diagnostic Cytopathology.2015; 43(4): 278.     CrossRef
• Multicentric solid pseudopapillary neoplasms of the pancreas diagnosed by endoscopic ultrasound-guided fine needle aspiration: a case report
  Megumi Yamaguchi, Toshikatsu Fukuda, Masahiro Nakahara, Mio Amano, Daisuke Takei, Masumi Kawashima, Yusuke Sumi, Hironobu Amano, Shuji Yonehara, Keiji Hanada, Toshio Noriyuki
  Surgical Case Reports.2015;[Epub]     CrossRef
• A solid pseudopapillary neoplasm without cysts that occurred in a patient diagnosed by endoscopic ultrasound-guided fine-needle aspiration: a case report
  Masakuni Fujii, Masao Yoshioka, Takefumi Niguma, Hiroaki Saito, Toru Kojima, Soichiro Nose, Junji Shiode
  Journal of Medical Case Reports.2014;[Epub]     CrossRef
• Surgical Management and Long-Term Follow-Up of Solid Pseudopapillary Tumor of Pancreas: A Large Series from a Single Institution
  Yunqiang Cai, Xun Ran, Siming Xie, Xin Wang, Bing Peng, Gang Mai, Xubao Liu
  Journal of Gastrointestinal Surgery.2014; 18(5): 935.     CrossRef
• A case of solid-pseudopapillary neoplasm in a middle-aged male preoperatively diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA)
  Shin KATO, Takuya HONBU, Moriya ZAKIMI, Kenji CHINEN, Tomiaki KUBOTA, Masayuki ARASHIRO, Kaoru KIKUCHI, Takahiro MURAKAMI, Fumihito KUNISHIMA
  Suizo.2014; 29(2): 263.     CrossRef
• Endoscopic ultrasound-guided fine needle aspiration improves the pre-operative diagnostic yield of solid-pseudopapillary neoplasm of the pancreas: an international multicenter case series (with video)
  Joanna K. Law, Alina Stoita, Wallia Weaver, Ferga C. Gleeson, Andrew M. Dries, Amanda Blackford, Vandhana Kiswani, Eun Ji Shin, Mouen A. Khashab, Marcia Irene Canto, Vikesh K. Singh, Anne Marie Lennon
  Surgical Endoscopy.2014; 28(9): 2592.     CrossRef
• Multiple Diagnostic Imaging of a Patient with Solid Pseudopapillary Tumour of the Pancreas: EUS, CT and FDG PET/CT
  Ari Chong, Jung-Min Ha, Seong Young Kwon
  Nuclear Medicine and Molecular Imaging.2014; 48(1): 82.     CrossRef